Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming.
Mark AleynickJudit Svensson-ArvelundGvantsa PantsulaiaKristy KimSamuel A RoseRanjan UpadhyayMichael YellinHenry MarshDaniel OreperSuchit JhunjhunwalaChristine Carine MoussionMiriam MeradBrian D BrownJoshua D BrodyPublished in: Journal for immunotherapy of cancer (2023)
This work provides rationale for the translation of pathogen vaccines as FDA-approved clinical-grade DC activators which could be exploited as immune-stimulants for early phase trials.