Gm40600 suppressed SP 2/0 isograft tumor by reducing Blimp1 and Xbp1 proteins.

Ying FangRuonan XuBing ZhaiChunmei HouNing MaLiang WangGencheng HanZhenyu JiangRenxi Wang

Published in: BMC cancer (2019)

Gm40600 reduced SP 2/0 cell proliferation and isograft tumor growth and progression by suppressing Blimp1 and Xbp1-mediated Bcl2 transcription to induce apoptosis. Thus, regulation of a human homolog of Gm40600, or associated factors, may be a potential therapeutic approach for treating MM.

Keyphrases

cell proliferation
endothelial cells
oxidative stress
endoplasmic reticulum stress
cell death
cell cycle arrest
cell cycle
transcription factor
pi k akt