Validation of PHASE for deriving N-acetyltransferase 2 haplotypes in the Western Cape mixed ancestry population.
Celeste SwartSurita MeldauChad M CentnerAdrian D MaraisFierdoz OmarPublished in: African journal of laboratory medicine (2020)
PHASE accurately predicted the phenotype in 92 of 93 samples (99%) from genotypic data in our mixed ancestry sample population, and is therefore a suitable alternative to molecular methods to individualise isoniazid therapy in this high burden tuberculosis setting.