Validation of PHASE for deriving N-acetyltransferase 2 haplotypes in the Western Cape mixed ancestry population.

Celeste Swart Surita Meldau Chad M Centner Adrian David Marais Fierdoz Omar

Published in: African journal of laboratory medicine (2020)

PHASE accurately predicted the phenotype in 92 of 93 samples (99%) from genotypic data in our mixed ancestry sample population, and is therefore a suitable alternative to molecular methods to individualise isoniazid therapy in this high burden tuberculosis setting.

Keyphrases

south africa
mycobacterium tuberculosis
emergency department
genome wide association study
pulmonary tuberculosis
big data
hiv aids
single molecule
mesenchymal stem cells
artificial intelligence
human immunodeficiency virus
data analysis
cell therapy
antiretroviral therapy
drug induced