Multicomponent Synthesis of Diverse o-Arylated Benzamides via o-Aminophenol (OAP) Directed C(sp2)-H Arylation.

o-Aminophenol (OAP) has been discovered as practical precursor of directing group (DG) in the palladium-catalyzed aromatic C-H arylation of benzamides. This newly identified, simple, and low cost DG has exhibited broad substrate tolerance in the rapid synthesis of various o-arylated benzamides via direct assemblies of benzoyl chlorides, aryl iodides, and different o-aminophenols in the form of step economical multicomponent reaction.