Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.

Vinothkumar RajamanickamTao YanLiangrong WuYanni ZhaoXiaohong XuHeping ZhuXi ChenMeihong WangZhoudi LiuZhiguo LiuGuang LiangYi Wang

Published in: Cancer management and research (2020)

In summary, our studies demonstrate that CA6 inhibited gastric cancer growth by inhibiting TrxR1 and increasing ROS, which in turn activated FoxO3a through suppressing Akt. CA6 is a potential candidate for the treatment of gastric cancer.

Keyphrases

cell death
signaling pathway
pi k akt
cell cycle arrest
cell proliferation
transcription factor
dna damage
protein kinase
reactive oxygen species
living cells
combination therapy
smoking cessation
replacement therapy