cjrABC-senB hinders survival of extraintestinal pathogenic E. coli in the bloodstream through triggering complement-mediated killing.
Wen-Chun HuangYi-Jyun LiaoMasayuki HashimotoKuan-Fu ChenChishih ChuPo-Chuen HsuShuying WangChing-Hao TengPublished in: Journal of biomedical science (2020)
The contribution of cjrABC-senB to the pathogenesis of ExPEC is niche dependent and contradictory because the genes facilitate ExPEC UTIs but hinder bacteremia. The contradictory niche-dependent characteristic may benefit the development of novel strategies against E. coli-caused infections.