A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells.

Jialiang YangJacob HagenKalyani V GunturKimaada AlletteSarah SchuylerJyoti RanjanFrancesca PetraliaStephane GestaRobert SebraMilind MahajanBin ZhangJun ZhuSander HoutenAndrew KasarskisVivek K VishnudasViatcheslav R AkmaevRangaprasad SarangarajanNiven R NarainEric E SchadtCarmen A ArgmannZhidong Tu

Published in: BMC genomics (2017)

Our study sheds new light on EV mediated RNA communications between adipocyte and macrophage cells, which may play a significant role in developing insulin resistance in diabetic patients. This work establishes a new method that is applicable to examining genetic material exchanges in many cellular systems and has the potential to be extended to in vivo studies as well.

Keyphrases

induced apoptosis
cell cycle arrest
adipose tissue
endoplasmic reticulum stress
copy number
insulin resistance
cell death
genome wide
gene expression
signaling pathway
oxidative stress
skeletal muscle
pi k akt