Decreased Hepatocyte Autophagy Leads to Synergistic IL-1β and TNF Mouse Liver Injury and Inflammation.
Yang ShenShoaib Ahmad MalikMuhammad AmirPradeep KumarFrancesca CingolaniJing WenYunshan LiuEnpeng ZhaoAlton B FarrisReben RaemanMark J CzajaPublished in: Hepatology (Baltimore, Md.) (2020)
The findings delineate mechanisms by which decreased hepatocyte autophagy promotes IL-1β/TNF-induced necrosis from impaired energy homeostasis and lysosomal permeabilization and inflammation through the secretion of exosomal damage-associated molecular patterns.