Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation.

Shiyang Wang Tianlong Wang Li WangLiansheng ZhongKai Li

Published in: OncoTargets and therapy (2020)

Overexpression of RNF126 was remarkably associated with multiple advanced clinical characters of CRC patients independent of mutant p53. RNF126 promotes cell proliferation, mobility, and drug resistance in CRC via enhancing p53 ubiquitination and degradation.

Keyphrases

cell proliferation
end stage renal disease
chronic kidney disease
dna damage response
transcription factor
peritoneal dialysis
prognostic factors
signaling pathway
pi k akt