Candida-reactive T cells for the diagnosis of invasive Candida infection of the lumbar vertebral spine.
Felix C KoehlerOliver Andreas CornelyHilmar WisplinghoffDe-Hua ChangAnne RichterPhilipp KöhlerPublished in: Mycoses (2017)
Invasive Candida infection is the fourth most common bloodstream infection. Blood cultures are the current gold standard diagnostic method, however, false negatives remain a clinical challenge. We developed a new technique measuring Candida-reactive T cells as diagnostic read-out for invasive Candida infection. In a pilot study, we followed the treatment course of a patient with an invasive Candida infection of the lumbar vertebral spine. We present the case of a 56-year-old patient with HIV-associated Burkitt lymphoma who developed septic shock during chemotherapy-induced neutropenia. For the first time, we provide flow cytometry-based diagnostics with Candida-reactive T cells for invasive candidiasis with comprehensive MRI imaging. The Candida-reactive T cell assay has potential to complement current diagnostic assays for invasive Candida infection and thus to support targeted treatment.
Keyphrases
- candida albicans
- biofilm formation
- flow cytometry
- minimally invasive
- high resolution
- magnetic resonance imaging
- chemotherapy induced
- septic shock
- bone mineral density
- staphylococcus aureus
- human immunodeficiency virus
- antiretroviral therapy
- case report
- hiv positive
- climate change
- magnetic resonance
- diffuse large b cell lymphoma
- mass spectrometry
- body composition
- hiv infected
- hiv aids
- combination therapy
- klebsiella pneumoniae
- hiv testing
- postmenopausal women
- human health