Anti-Tyrosinase Compounds from the Deep-Sea-Derived Actinomycete Georgenia sp. 40DY180.
Jianwei ChenSiqi WangYiming XuHua-Wei ZhangHong WangPublished in: Chemistry & biodiversity (2022)
With the aim of finding new marine-derived skincare promoters, an assay-guided approach was employed to discover tyrosinase-modulating compounds from marine actinomycete. Here we describe a new 2,5-piperazinedione, named georgenione A (1), together with two previously described compounds, 5-(4'-hydroxybenzyl)hydantoin (2) and cyclo(Trp-Gly) (3), produced by actinomycete Georgenia sp. 40DY180, isolated from deep-sea sediments collected in the Pacific Ocean. Their structures were elucidated by a combination of spectroscopic analyses including 1D and 2D NMR and high-resolution mass spectrometric data. 5-(4'-hydroxybenzyl)hydantoin (2) displayed in vitro potent anti-tyrosinase activity with IC 50 value of 36 μM, comparable to the commercially used positive control kojic acid (IC 50 =46 μM) and arbutin (IC 50 =100 μM). Compounds 1-3 were firstly reported from marine actinomycete Georgenia sp.