PIGT promotes cell growth, glycolysis, and metastasis in bladder cancer by modulating GLUT1 glycosylation and membrane trafficking.

Mingyue TanQi PanChao YuXinyu ZhaiJianyi GuLe TaoDongliang Xu

Published in: Journal of translational medicine (2024)

WTAP mediates PIGT m6A modification to increase the stability of PIGT via the IGF2BP2, which enhances cell proliferation, glycolysis, and metastasis in bladder cancer by modulating GLUT1 glycosylation and membrane trafficking.

Keyphrases

cell proliferation
signaling pathway
pi k akt
cell cycle
binding protein