A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer.
Chelsea MayohAndrew J GiffordRachael TerryLoretta M S LauMarie WongPadmashree RaoTyler Shai-HeeFederica SalettaDong-Anh Khuong-QuangVicky QinMarion K MateosDeborah MeyranKatherine E MillerAysen YukselEmily V A MouldRachel Bowen-JamesDinisha GovenderAkanksha SenapatiNataliya ZhukovaNatacha OmerHetal DholariaFrank AlvaroHeather TappYonatan DiamondLuciano Dalla PozzaAndrew S MooreWayne NichollsNicholas G GottardoGeoffrey McCowageJordan R HansfordSeong-Lin KhawPaul J WoodDaniel CatchpooleCatherine E CottrellElaine R MardisGlenn M MarshallVanessa TyrrellMichelle HaberDavid S ZieglerOrazio VittorioJoseph A TrapaniMark J CowleyPaul J NeesonPaul G EkertPublished in: Genome medicine (2023)
Our data provides new insights into the variable immune-suppressive mechanisms dampening responses in paediatric solid cancers. Effective immune-based interventions in high-risk paediatric cancer will require individualised analysis of the TIME.