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Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases.

Daniela AndriutaJulie OttoyMyuri RuthirakuhanGinelle FelicianoAllison A DilliottRobert A HegeleFuqiang GaoPaula M McLaughlinJennifer S RabinMadeline Wood AlexanderChristopher J M ScottVanessa YhapCourtney BerezukMiracle OzzoudeWalter SwardfagerJulia ZebarthM Carmela TartagliaEkaterina RogaevaDavid F Tang-WaiLeanne CasaubonSanjeev KumarDar DowlatshahiJennifer MandziaDemetrios SahlasGustavo SaposnikCorinne E FischerMichael BorrieAyman HassanMalcolm A BinnsMorris FreedmanHoward ChertkowElizabeth FingerAndrew FrankRobert BarthaSean SymonsHenrik ZetterbergRichard H SwartzMario MasellisSandra E BlackJoel Ramireznull null
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Perivascular spaces (PVS) and white matter hyperintensities (WMH) are imaging markers of small vessel disease. Plasma glial fibrillary protein acidic protein (GFAP) is a biomarker of astroglial injury. PVS, WMH, and GFAP are relevant in executive dysfunction from neurodegeneration. PVS's effect on executive function was mediated by GFAP and white matter disease.
Keyphrases
  • white matter
  • multiple sclerosis
  • protein protein
  • high resolution
  • binding protein
  • amino acid
  • oxidative stress
  • working memory
  • ionic liquid
  • neuropathic pain
  • small molecule
  • spinal cord
  • spinal cord injury