PD-1 + mast cell enhanced by PD-1 blocking therapy associated with resistance to immunotherapy.

Jun LiGang PengKuikui ZhuXiaohua JieYingzhuo XuXinrui RaoYunhong XuYunshang ChenBiyuan XingGang WuLiang-Liang Shi

Published in: Cancer immunology, immunotherapy : CII (2022)

mast cell activated by PD-1 antibody plays a negative role in the tumor microenvironment via the enhanced function of releasing histamine and cytokines. Inhibition of mast cell may provide a new solution to solve the low response rate of anti-PD-1 immunotherapy.

Keyphrases

stem cells
cell therapy
chemotherapy induced