Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia.

Emily R FinchColton A SmithWenjian YangYiwei LiuNancy M KornegayJohn C PanettaKristine R CrewsAlejandro R MolinelliCheng ChengDeqing PeiLaura B RamseySeth E KarolHiroto InabaJohn T SandlundMonika MetzgerWilliam E EvansSima JehaChing-Hong Pui Mary V Relling

Published in: Pediatric blood & cancer (2019)

Triglycerides were affected more by PEG-asparaginase than native l-asparaginase, by asparaginase more than dexamethasone, and by drug effects more than genetics. It is not clear whether triglycerides contribute to thrombosis and osteonecrosis or are biomarkers of the toxicities.

Keyphrases

acute lymphoblastic leukemia
drug delivery
pulmonary embolism
low dose
high density
high dose
acute myeloid leukemia
drug induced
adverse drug