Dopamine pathway and Parkinson's risk variants are associated with levodopa-induced dyskinesia.
Yuri L SoseroSara Bandres-CigaBart FerwerdaMaria T P TocinoDìaz R BellosoPilar Gómez-GarreJohann FaouziPille TabaLukas PavelkaTainà M MarquesClarissa P C GomesAlexey KolodkinPatrick MayLukasz M MilanowskiZbigniew K WszolekRyan J UittiPeter HeutinkJacobus J van HiltenDavid K SimonShirley EberlyIgnacio AlvarezLynne KrohnEric YuKathryn FreemanUladzislau RudakouJennifer A RuskeyFarnaz AsayeshManuel Menéndez-GonzàlezPau PastorOwen A RossRejko KrügerJean-Christophe CorvolSulev KõksPablo MirRob M A de BieHirotaka IwakiZiv Gan-OrPublished in: medRxiv : the preprint server for health sciences (2023)
This study suggests that variants implicated in PD and in the dopaminergic transmission pathway play a role in the risk/time to develop LID. Further studies will be necessary to examine how these findings can inform clinical care.