Bone marrow and plasma FGF-23 in heart failure patients: novel insights into the heart-bone axis.

Beatrice von JeinsenKateryna SopovaLars PalapiesDavid M LeistnerStephan FichtlschererFlorian H SeegerJörg HonoldStefanie DimmelerBirgit AßmusAndreas M ZeiherSteffen D Kriechbaum

Published in: ESC heart failure (2019)

In CHF patients, FGF-23 is elevated in bone marrow plasma and is independently associated with heart failure severity and all-cause mortality. The failing heart seems to interact via FGF-23 within a heart-bone axis.

Keyphrases

heart failure
bone marrow
ejection fraction
end stage renal disease
mesenchymal stem cells
atrial fibrillation
bone mineral density
newly diagnosed
chronic kidney disease
soft tissue
prognostic factors
peritoneal dialysis
postmenopausal women
acute heart failure
body composition