Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes.
Cindy GueguenSandra L BurkeBenjamin BarzelNina EikelisAnna M D WatsonJay C JhaKristy L JacksonYusuke SataKyungjoon LimGavin W LambertKarin A M Jandeleit-DahmMark E CooperMerlin C ThomasGeoffrey A HeadPublished in: Diabetologia (2020)
As empagliflozin can restore diabetes-induced augmented sympathetic reflexes, this may be beneficial in diabetic patients. A similar action of the diuretic acetazolamide suggests that the mechanism may involve increased sodium and water excretion. Graphical abstract.