Prospective clinical trial testing COXEN-based gene expression models of chemosensitivity in dogs with spontaneous osteosarcoma.
Daniel L GustafsonKeagan P CollinsJared S FowlesE J EhrhartKristen M WeishaarSunetra DasDawn L DuvalDouglas H ThammPublished in: Cancer chemotherapy and pharmacology (2021)
The COXEN predictor of chemosensitivity to CARBO or DOX is not a significant predictor of outcome when utilized in this prospective study. This trial represents the first prospective trial of a GEM predictor of chemosensitivity and establishes pet dogs with cancer as viable surrogates for prospective trials of prognostic indicators.