Interleukin-25 is involved in cutaneous T-cell lymphoma progression by establishing a T helper 2-dominant microenvironment.

R NakajimaTomomitsu MiyagakiM HirakawaT OkaN TakahashiH SugaA YoshizakiH FujitaY AsanoM SugayaS Sato

Published in: The British journal of dermatology (2018)

Th2 cytokines highly expressed in CTCL lesional skin induce IL-25 production by epidermal keratinocytes, which may, in turn, lead to formation of a Th2-dominant microenvironment through the direct induction of IL-13 by tumour cells.

Keyphrases

wound healing
induced apoptosis
stem cells
cell cycle arrest
regulatory t cells
dendritic cells
soft tissue
sensitive detection
endoplasmic reticulum stress
fluorescent probe
oxidative stress
signaling pathway
cell death
pi k akt
single molecule