Effect of bisphosphonates and statins on the in vitro radiosensitivity of breast cancer cell lines.

Larry BodgiJolie Bou-GhariosJoyce AzziRafka ChallitaCharbel FeghalyKhanom BaalbakiHussein KharroubiFatima ChhadeFady GearaWassim Abou-KheirZeina Ayoub

Published in: Pharmacological reports : PR (2023)

Our findings show that pretreatment with ZOPRA can decrease the radioresistance of breast cancer cells at the molecular and cellular levels. The fact that ZOPRA was previously shown to radioprotect normal tissues, makes it a good candidate to become a therapeutic window-widening drug.

Keyphrases

breast cancer cells
cardiovascular disease
gene expression
dna damage response
adverse drug
single molecule
cancer stem cells
emergency department