Association between mandibular prognathism and Matrilin-1, bone morphogenic protein, Tyr67Asn, homeobox protein hox-A2, Rho-GTPase activating protein, and Myosin 1H genes in the Indian population.
Anish DokeAnand SabaneAmol PatilJayesh RahalkarTulsi SubramaniamMonali NikaljePublished in: Folia medica (2024)
Mandibular prognathism (MP) patients present with aesthetic concerns and functional issues, including difficulties in mastication and pronunciation. Studies revealed that mandibular prognathism had definitive Mendelian inheritance patterns. This study aimed to ascertain distinct genetic markers associated with mandibular prognathism in individuals of Indian descent, focusing on exploring the prevalent genetic variations associated with certain genes. This study sought to identify the association of the following gene markers with mandibular prognathism: 1) Matrilin-1 (MATN1) (rs1065755), 2) Bone morphogenic protein 3 (BMP-3) (Tyr67Asn), 3) Homeobox protein hox-A2 (HOXA2) (Val327Ile), 4) Rho-GTPase activating protein (ARHGAP 21) (Gly1121Ser), 5) Myosin 1H (MYO1H) (rs10850110).
Keyphrases
- binding protein
- genome wide
- protein protein
- amino acid
- end stage renal disease
- copy number
- signaling pathway
- mesenchymal stem cells
- newly diagnosed
- chronic kidney disease
- gene expression
- ejection fraction
- long non coding rna
- mitochondrial dna
- genome wide identification
- peritoneal dialysis
- prognostic factors
- bone loss
- bioinformatics analysis