Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort.
Sindhu PandurangiReena MouryaShreya NalluriLin FeiShun DongSanjiv HarpavatStephen L GutheryJean P MollestonPhilip RosenthalRonald J SokolKasper S WangVicky Lee NgEstella M AlonsoKatelyn M SaarelaSaul J KarpenKathleen M LoomesJohn C MageeBenjamin L ShneiderSimon Peter HorslenJeffrey H TeckmanJorge A Bezerranull nullPublished in: Hepatology (Baltimore, Md.) (2024)
Serum MMP-7 has high discriminative properties to differentiate BA from other forms of neonatal cholestasis. MMP-7 cutoff values vary according to assay technology. Using MMP-7 in the evaluation of infants with cholestasis may simplify diagnostic algorithms and shorten the time to hepatoportoenterostomy.