Detection of cryptogenic malignancies from metagenomic whole genome sequencing of body fluids.
Wei GuEric TalevichElaine HsuZhongxia QiAnatoly UrismanScot FedermanAllan GopezShaun ArevaloMarc GottschallLinda LiaoJack TungLei ChenHarumi LimChandler HoMaya KasowskiJean OakBrittany J HolmesIwei YehJingwei YuLinlin WangSteve MillerJoseph L DeRisiSonam PrakashJeff SimkoCharles Y ChiuPublished in: Genome medicine (2021)
Metagenomic sequencing of body fluids can be used to identify undetected malignant neoplasms through copy number variation detection. This study illustrates the potential clinical utility of a single metagenomic test to uncover the cause of undiagnosed acute illnesses due to cancer or infection using the same specimen.
Keyphrases
- copy number
- mitochondrial dna
- antibiotic resistance genes
- loop mediated isothermal amplification
- real time pcr
- genome wide
- label free
- liver failure
- papillary thyroid
- single cell
- respiratory failure
- squamous cell
- wastewater treatment
- intensive care unit
- risk assessment
- climate change
- lymph node metastasis
- aortic dissection
- anaerobic digestion
- quantum dots
- childhood cancer