Systemic viral infection in children receiving chemotherapy for acute leukemia.
Constanze Buus-GehrigKonrad BochennekMarc T HenniesThomas KlingebielAndreas H GrollThomas LehrnbecherPublished in: Pediatric blood & cancer (2020)
Systemic viral diseases frequently occur in allogeneic hematopoietic stem cell transplantation, but data in children receiving chemotherapy for acute leukemia are scarce. We therefore collected and analyzed the published data on symptomatic infection from cytomegalovirus, herpes simplex virus, varicella zoster virus, parvovirus B19, or adenovirus in pediatric acute leukemia. Reports on 68 children were identified, of whom 16 patients have died from the infection. Further studies have to (1) evaluate the true incidence of these infections in pediatric acute leukemia, (2) their impact on outcome, and (3) whether a subpopulation of patients could benefit from screening and prophylactic strategies.
Keyphrases
- end stage renal disease
- allogeneic hematopoietic stem cell transplantation
- young adults
- chronic kidney disease
- peritoneal dialysis
- acute myeloid leukemia
- herpes simplex virus
- emergency department
- squamous cell carcinoma
- acute lymphoblastic leukemia
- systematic review
- machine learning
- radiation therapy
- patient reported
- adverse drug