Senescence and senolysis in cancer: The latest findings.
Yoshimi ImawariMakoto NakanishiPublished in: Cancer science (2024)
Aging is a life phenomenon that occurs in most living organisms and is a major risk factor for many diseases, including cancer. Cellular senescence is a cellular trait induced by various genomic and epigenetic stresses. Senescent cells are characterized by irreversible cell growth arrest and excessive secretion of inflammatory cytokines (senescence-associated secretory phenotypes, SASP). Chronic tissue microinflammation induced by SASP contributes to the pathogenesis of a variety of age-related diseases, including cancer. Senolysis is a promising new strategy to selectively eliminate senescent cells in order to suppress chronic inflammation, suggesting its potential use as an anticancer therapy. This review summarizes recent findings on the molecular basis of senescence in cancer cells and senolysis.
Keyphrases
- papillary thyroid
- induced apoptosis
- dna damage
- endothelial cells
- squamous cell
- cell cycle arrest
- oxidative stress
- dna methylation
- gene expression
- stem cells
- childhood cancer
- cell cycle
- cell death
- endoplasmic reticulum stress
- genome wide
- multidrug resistant
- weight gain
- copy number
- physical activity
- cell proliferation
- gram negative
- smoking cessation