Stereocontrolled synthesis of the aconitine D ring from D-glucose.
Ian A PocockJulien DoulcetCraig R RiceJoseph B SweeneyDuncan M GillPublished in: Organic & biomolecular chemistry (2024)
The synthesis of a fully oxygenated aconitine D ring precursor from (D)-(+)-glucose is described. The route features a highly diastereoselective alkynyl Grignard ketone addition and a base-mediated enelactone to 1,3-diketone rearrangement.
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