A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents.
Sofia Moran-RamosLuis Macias-KaufferBlanca E López-ContrerasHugo Villamil-RamírezElvira Ocampo-MedinaPaola León-MimilaBlanca E Del Rio-NavarroOmar Granados-PortilloIsabel Ibarra-GonzalezMarcela Vela-AmievaArmando R TovarNimbe TorresFrancisco J Gomez-PerezCarlos Aguilar-SalinasSamuel Canizales-QuinterosPublished in: Molecular medicine (Cambridge, Mass.) (2021)
We provide evidence that gut bacterial BCAA transport genes, mainly encoded by Faecalibacterium prausnitzii, are associated with lower circulating BCAA and lower insulin resistance. Based on the later, we propose that the relationship between Faecalibacterium prausnitzii and insulin resistance, could be through modulation of BCAA.