Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains.
Jinbin XuJianjun SunRichard J PerrinRobert H MachKelly R BalesJohn C MorrisTammie L S BenzingerDavid M HoltzmanPublished in: Annals of clinical and translational neurology (2019)
This distinct pattern of TSPO density change in late stage AD and DLB cases may imply the occurrence of microglia dystrophy in late stage neurodegeneration. Furthermore, TSPO may not only be a microglia activation marker in early stage AD and DLB, but TSPO may also be used to monitor microglia dysfunction in the late stage of these diseases.