Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.

Humaira RasheedLisa K StampNicola DalbethTony Raymond Merriman

Published in: Arthritis research & therapy (2017)

These data support the hypothesis that alcohol influences the risk of gout via glucose and apolipoprotein metabolism. In the absence of alcohol exposure, genetic variants in the GCKR and A1CF genes have a stronger role in gout.

Keyphrases

alcohol consumption
uric acid
cystic fibrosis
genome wide
metabolic syndrome
electronic health record
big data
type diabetes
gene expression
blood pressure
machine learning
transcription factor
bioinformatics analysis
genome wide analysis
genome wide association