Acute Effects of Heated Tobacco Product (IQOS) Aerosol Inhalation on Lung Tissue Damage and Inflammatory Changes in the Lungs.
Tariq A BhatSuresh G KalathilNoel LeighThivanka MuthumalageIrfan RahmanMaciej Lukasz GoniewiczYasmin M ThanavalaPublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2021)
Exposure of mice to IQOS, one of the candidate modified-risk tobacco products, induces inflammatory immune-cell accumulation in the lungs and augments the levels of proinflammatory cytokines and chemokines in the BAL fluid. Such an exacerbated pulmonary proinflammatory microenvironment is associated with lung epithelial-cell damage in IQOS-exposed mice, suggesting a potential association with the impairment of lung function.
Keyphrases
- lung function
- oxidative stress
- high fat diet induced
- chronic obstructive pulmonary disease
- cystic fibrosis
- air pollution
- liver failure
- stem cells
- pulmonary hypertension
- respiratory failure
- drug induced
- wild type
- insulin resistance
- type diabetes
- hepatitis b virus
- adipose tissue
- water soluble
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome