Cannabinoid Receptor 2-Centric Molecular Feedback Loop Drives Necroptosis in Diabetic Heart Injuries.

Pan Gao Mengying CaoXueli JiangXiaolin WangGuoping ZhangXinru TangChunjie YangIssei Komuro Jun-Bo Ge Liliang Li Yunzeng Zou

Published in: Circulation (2022)

CB2R transcriptionally repressed necroptosis through interaction with BACH2; in turn, MLKL formed a negative feedback to phosphorylate CB2R. Our study provides the integrative view of a novel molecular mechanism loop for regulation of necroptosis centered by CB2R, which represents a promising alternative strategy for controlling diabetic heart dysfunction.

Keyphrases

type diabetes
heart failure
wound healing
transcription factor
atrial fibrillation
oxidative stress
fluorescent probe