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GATA2 regulates blood/lymph separation in a platelet-dependent and lymphovenous valve-independent manner.

Md Riaj MahamudXin GengLijuan ChenZoheb AhmedYen-Chun HoRajanarayanan Sathishkumar Srinivasan
Published in: Microcirculation (New York, N.Y. : 1994) (2022)
GATA2 promotes blood/lymph separation through platelets. Furthermore, LVVs are the only known sites of interaction between blood and lymphatic vessels. The fact that blood is able to enter the lymphatic vessels of mice lacking LVVs and platelets indicates that under these circumstances the lymphatic and blood vessels are connected at yet to be identified sites.
Keyphrases
  • lymph node
  • transcription factor
  • aortic valve
  • heart failure
  • mitral valve
  • mass spectrometry
  • coronary artery disease
  • metabolic syndrome
  • atrial fibrillation
  • transcatheter aortic valve replacement
  • wild type