Mucosal glucagon-like peptide 1 (GLP-1) responses are mediated by calcitonin gene-related peptide (CGRP) in the mouse colon and both peptide responses are area-specific.

I R ToughR MoodaleyHelen M Cox

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2017)

GLP-1 modulates epithelial ion transport indirectly by activating CGRP-containing submucosal enteric neurons in the mouse colon. This GLP-1-CGRP response was area-specific and could potentially contribute to the diarrheal side effect of certain GLP-1R therapeutics.

Keyphrases

small molecule
spinal cord
copy number
spinal cord injury
dna methylation