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Efficacy and safety of single-dose 40 mg/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: An individual participant data meta-analysis.

Piero L OlliaroJean T CoulibalyAmadou GarbaChristine HalleuxJennifer KeiserCharles H KingFrancisca MutapiEliézer K N'GoranGiovanna RasoAlexandra U ScherrerJosé Carlos Sousa-FigueiredoKatarina SteteJürg UtzingerMichel T Vaillant
Published in: PLoS neglected tropical diseases (2020)
There is no indication that single-dose 40 mg/kg oral praziquantel would be less efficacious and less safe in preschool-age children compared to school-age children, with the caveat that only few randomized comparisons exist between the two age groups. Preventive chemotherapy might therefore be extended to preschool-age children, with proper monitoring of its efficacy and safety.
Keyphrases
  • young adults
  • systematic review
  • clinical trial
  • squamous cell carcinoma
  • machine learning
  • electronic health record
  • double blind
  • rectal cancer
  • big data
  • placebo controlled