Efficacy and safety of single-dose 40 mg/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: An individual participant data meta-analysis.
Piero L OlliaroJean T CoulibalyAmadou GarbaChristine HalleuxJennifer KeiserCharles H KingFrancisca MutapiEliézer K N'GoranGiovanna RasoAlexandra U ScherrerJosé Carlos Sousa-FigueiredoKatarina SteteJürg UtzingerMichel T VaillantPublished in: PLoS neglected tropical diseases (2020)
There is no indication that single-dose 40 mg/kg oral praziquantel would be less efficacious and less safe in preschool-age children compared to school-age children, with the caveat that only few randomized comparisons exist between the two age groups. Preventive chemotherapy might therefore be extended to preschool-age children, with proper monitoring of its efficacy and safety.