HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
Qiuran XuJianfeng TuChangwei DouJun ZhangLiu YangXin LiuKefeng LeiZhikui LiuYufeng WangLijie LiHangxing BaoJiahui WangKangsheng TuPublished in: Molecular cancer (2017)
We suggest that HSP90 potentiates the glycolysis and proliferation, reduces the apoptosis and thus enhances the growth of HCC cells through PKM2.