Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation.
Yi Rang NaDaun JungMichelle StakenborgHyeri JangGyo Jeong GuMi Reu JeongSoo Youn SuhHak Jae KimYoon Hey KwonTae Sik SungSeung Bum RyooKyu Joo ParkJong Pil ImJi Yong ParkYun Sang LeeHeonjong HanBoyoun ParkSungwook LeeDaesik KimHo Su LeeIsabelle CleynenGianluca MatteoliSeung Hyeok SeokPublished in: Gut (2021)
PTGER4+ intestinal macrophages are essential for supporting the intestinal stem cell niche and regeneration of the injured epithelium. Our results pave the way for the development of a new class of therapeutic targets to promote macrophage healing functions and favour remission in patients with IBD.