A 3'-pre-tRNA-derived small RNA tRF-1-Ser regulated by 25(OH)D promotes proliferation and stemness by inhibiting the function of MBNL1 in breast cancer.

Xinyu WanWenjie ShiLingjun MaLexin WangRan ZhengJinzhi HeYe WangXuan LiXiaoming ZhaJue WangLu Xu

Published in: Clinical and translational medicine (2024)

In brief, our research revealed a novel anticancer mechanism of 25(OH)D, unveiled the vital function of tRF-1-Ser in BRCA progression, and suggested that tRF-1-Ser could emerge as a new therapeutic target for BRCA.

Keyphrases

signaling pathway
breast cancer risk
stem cells
epithelial mesenchymal transition
single cell
young adults
nucleic acid