Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway.
Xiaolu ZhangJuntian LiuXiaoming PangJingjing ZhaoShouzhu XuPublished in: Evidence-based complementary and alternative medicine : eCAM (2020)
Aldosterone regulates the initiation and development of atherosclerosis which is identified as a chronic inflammatory disease by promoting the generation of C-reactive protein in vascular smooth muscle cells. Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation effects. Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored. Primary rat vascular smooth muscle cells and hyperaldosteronism model rats were used in this study. The amount of C-reactive protein, reactive oxygen species, and the signaling pathway-related molecules generated were estimated. We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway. The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin.
Keyphrases
- vascular smooth muscle cells
- angiotensin ii
- signaling pathway
- reactive oxygen species
- oxidative stress
- diabetic rats
- pi k akt
- high glucose
- smooth muscle
- drug induced
- anti inflammatory
- dna damage
- induced apoptosis
- cell proliferation
- cardiovascular disease
- cell death
- type diabetes
- endothelial cells
- stress induced
- human health