Aptamers: The Powerful Molecular Tools for Virus Detection.
Cong HanQian LiHaishuo JiWenping XingLimin ZhangLiyun ZhangPublished in: Chemistry, an Asian journal (2021)
Aptamers are short single-stranded DNA or RNA oligonucleotides selected by the technique of systematic evolution of ligands by exponential enrichment (SELEX). Aptamers have been demonstrated to bind various targets from small-molecule to cells or even tissues in the way of antibodies. Thus, they are called chemical antibodies. We summarize and evaluate recent developments in aptamer-based sensors (for short aptasensors) for virus detection in this review. These aptasensors are mainly classified into optical and electronic aptasensors based on the type of transducer. Nowadays, the smartphone has become the most widely used mobile device with billions of users worldwide. Considering the ongoing COVID-19 outbreak, smartphone-based aptasensors for a portable and point-of-care test (POCT) of COVID-19 detection will be of great importance in the future.
Keyphrases
- nucleic acid
- small molecule
- label free
- loop mediated isothermal amplification
- real time pcr
- coronavirus disease
- sars cov
- induced apoptosis
- gene expression
- sensitive detection
- gold nanoparticles
- high resolution
- circulating tumor
- cell death
- cell free
- current status
- low cost
- cell cycle arrest
- cell proliferation
- binding protein
- high speed
- respiratory syndrome coronavirus
- protein protein