Placental transfer and tissue accumulation of dolutegravir in the ex vivo human cotyledon perfusion model.

Laurent Mandelbrot Pierre-François CeccaldiDominique DuroMinh LêLucile PencoléGilles Peytavin

Published in: PloS one (2019)

Fetal transplacental exposure to dolutegravir was considerable as well as accumulation in placental tissue. Whether this may lead to risks for the exposed fetus requires more investigation.

Keyphrases

endothelial cells
hiv infected patients
antiretroviral therapy
magnetic resonance imaging
induced pluripotent stem cells
human health
contrast enhanced
computed tomography