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Visible-light-promoted direct C3-trifluoromethylation and perfluoroalkylation of imidazopyridines.

Meichen LiGaolin LiChenxun DaiWenjun ZhouWenqiang ZhanMuyang GaoYuan RongZe TanWei Deng
Published in: Organic & biomolecular chemistry (2021)
An efficient method for direct trifluoromethylation and perfluoroalkylation at C3 of imidazopyridines through visible light-promoted C-H bond functionalization was developed. Under the irradiation of a blue LED, a series of C3-perfluoroalkyl-substituted imidazopyridines were synthesized from the corresponding imidazopyridines and perfluoroalkyl iodides in moderate to good yields at room temperature. It should be mentioned that this reaction proceeded in the absence of any transition-metal catalyst, oxidant and photocatalyst.
Keyphrases
  • visible light
  • room temperature
  • transition metal
  • ionic liquid
  • high intensity
  • molecular docking
  • light emitting
  • radiation induced
  • molecular dynamics simulations
  • electron transfer