LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1.
Hengzhi DuYanru ZhaoJianpei WenBeibei DaiGuo HuYufei ZhouZhongwei YinNan DingHuaping LiJiahui FanXiang NieFeng WangQian LiuZheng WenGang XuDao-Wen WangChen ChenPublished in: Circulation (2024)
Our study revealed that the loss of DCRT contributed to PTBP1-mediated exon skipping of NDUFS2, thereby inducing cardiac mitochondrial dysfunction during dilated cardiomyopathy development, which could be partially treated with coenzyme Q10 supplementation.