Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.
Elisabet JohanssonJocelyn M Biagini MyersLisa J MartinHua HePatrick RyanGrace K LeMastersDavid I BernsteinJames LockeyGurjit K Khurana HersheyPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
KIF3A interacted differentially with sensitization pattern to increase the risk of asthma in two high-risk groups of children with and without early eczema. Given the reported role of KIF3A in epithelial cell functioning, the results add evidence to the hypothesis that an impaired epithelial barrier is a key aspect in the development of allergic disease.