Low pre-ART CD4 count is associated with increased risk of clinical progression or death even after reaching 500 CD4 cells/μL on ART.

Nikos PanatzisVasilios PaparizosVasilios PapastamopoulosSimeon MetallidisAnastasia AntoniadouGeorgios AdamisMina PsichgiouMaria ChiniHelen SambatakouGeorgios ChrysosNikolaos V SipsasCharalambos GogosEmmanouil BarbunakisPeriklis PanagopoulosOlga KatsarouGiota Toulouminull null

Published in: PloS one (2023)

Individuals starting ART with <200 cells/μL remain on increased risk even after reaching 500 CD4 cells/μL. These patients should be closely followed.

Keyphrases

induced apoptosis
cell cycle arrest
end stage renal disease
endoplasmic reticulum stress
hiv infected
chronic kidney disease
newly diagnosed
antiretroviral therapy
signaling pathway
cell proliferation