In Vitro Comparison of the Role of P-Glycoprotein and Breast Cancer Resistance Protein on Direct Oral Anticoagulants Disposition.

Sophie HodinThierry BassetElodie JacquerouxOlivier DelezayAnthony ClotagatideNathalie PerekPatrick MismettiXavier Delavenne

Published in: European journal of drug metabolism and pharmacokinetics (2018)

This study allowed identification of three different profiles of ABC carrier-mediated transport: predominantly P-gp-dependent transport (dabigatran), preferential BCRP-dependent transport (apixaban) and approximately equivalent P-gp and BCRP-mediated transport (edoxaban and rivaroxaban).

Keyphrases

venous thromboembolism
direct oral anticoagulants
atrial fibrillation
pulmonary embolism
small molecule
binding protein