The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.
Eleni GeorgiadouElizabeth HaythorneMatthew T DickersonLivia Lopez-NoriegaTimothy J PullenGabriela da Silva XavierSamuel P X DavisAida Martinez-SanchezFrancesca SempliciRosario RizzutoJames A McGintyPaul M FrenchMatthew C CaneDavid A JacobsonIsabelle LeclercGuy A RutterPublished in: Diabetologia (2020)
MCU is crucial for mitochondrial Ca2+ uptake in pancreatic beta cells and is required for normal GSIS. The apparent compensatory mechanisms that maintain glucose tolerance in βMcu-KO mice remain to be established.