Toxicity assessment of synthetic chalcones with antileishmanial potential in BALB/c mice.

Karina Cancino Ines Castro Dionicio Carlos Yauri Valérie Jullian Jorge Arévalo Michel Sauvain Vanessa Adaui Denis Castillo

Published in: Revista peruana de medicina experimental y salud publica (2021)

The LD50 for all three chalcones was greater than 550 mg/kg of body weight. Chalcones 40 and 42 were found to be relatively non-toxic. Both can be considered safe for intraperitoneal application in BALB/c mice and, consequently, are potential candidates for use in the treatment of leishmaniasis.

Keyphrases

body weight
high fat diet induced
oxidative stress
type diabetes
insulin resistance
wild type
metabolic syndrome
risk assessment
adipose tissue
skeletal muscle
climate change