Association of autoantibody concentrations and trajectories with lupus nephritis histological features and treatment response.
Andrea FavaCatriona A WagnerCarla J GuthridgeJoseph KheirSusan MacwanaWade DeJagerTim GrossPeter IzmirlyH Michael BelmontBetty DiamondAnne DavidsonPaul J UtzMichael H WeismanLaurence S Magdernull nullJoel M GuthridgeMichelle A PetriJill P BuyonJudith A JamesPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Baseline levels of anti-C1q and -dsDNA may serve as noninvasive biomarkers of proliferative LN, and anti-C1q may predict complete response at the time of kidney biopsy. In addition, tracking autoantibodies over time may provide further insights into treatment response and pathogenic mechanisms in proliferative LN patients.